Direct effects of high concentrations of dimethylsulfoniopropionate, vitamin E and ferulic acid on the senility of aged scenescene-accelerated mouse (SAMP8).
نویسنده
چکیده
The effects of high concentrations of dimethylsulfoniopropionate (DMSP), vitamin E and ferulic acid solutions on the aging of male and female scenescene-accelerated mouse (SAMP8) at the age of 50 wk were examined by direct supplementation to their stomachs twice a week for 28-30 d. The addition of 1 mL of DMSP, vitamin E and ferulic acid solutions (21% each) to the male and female mice in each group in this order rather elevated their growth and significantly suppressed their total grading score and loss of learning and memory with increasing rearing times for the short experimental period. However, there were no significant differences found between the male and female mice during the experimental period. The antioxidant and hormonal actions for the effects of the test compounds on the aged SAMP8 were possibly considered.
منابع مشابه
Significant effect of dimethylsulfoniopropionate on Parkinson's disease of senescence-accelerated mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
The induction of Parkinson's disease (PD) in senescence-accelerated mice (SAMP8) by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the effects of dimethylsulfoniopropionate (DMSP) on induced PD model mice of SAMP8 were investigated for 5 wk. After many trials, the tail suspension test determining the PD symptoms indicated that an appropriate amount of MPTP clearly raises the SAMP8 mice...
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ورودعنوان ژورنال:
- Journal of nutritional science and vitaminology
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2004